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Eintrag vom: 01.11.2013.

Coronary artery disease (CAD) develops when plaque builds up in the coronary arteries causing them to become narrow or blocked. It can lead to a heart attack but statins and other treatment ...

 

Statins at conventional doses have demonstrated the linear relationship between reduction in LDL-c and reduction in cardiovascular (CV) events; they increase life expectancy in primary and secondary prevention.

 

Statin therapy is a cornerstone in the management of Coronary Artery Disease (CAD). To appreciate its significance it's essential to understand how statins work and their benefits in CAD management. Statins are a class of lipid-lowering medications that inhibit the enzyme HMG-CoA reductase.

 

Patients were stratified at each center by baseline LDL cholesterol levels (higher than 100 mg/dL) acute coronary syndrome (ACS) or diabetes. Also patients in both groups were randomized to receive rosuvastatin or atorvastatin.

 

Although statins are recommended for decreasing cardiovascular risk their efficacy across different patient phenotypes stratified by coronary artery disease (CAD) remains unclear.

 

Lipid-lowering is the cornerstone of secondary prevention for vascular events in patients with coronary artery disease (CAD).

 

High-intensity statin therapy is recommended for patients with coronary artery disease (CAD) to reduce LDL cholesterol by at least 50% from baseline as it has been shown to reduce major vascular events by approximately 15% compared to moderate-intensity statins 1.

 

Clinical trials have shown that statin therapy reduces cardiovascular morbidity and mortality in patients with coronary artery disease (CAD) even among patients with low-density lipoprotein (LDL) levels <100mg/dL.

 

Background?Clinical trials have shown that statin therapy reduces cardiovascular morbidity and mortality in patients with coronary artery disease (CAD) even among patients with low-density lipoprotein cholesterol levels 100 mg/dL.